| Administrative areas | |
|---|---|
| Flows into | |
| Towns (upstream to downstream) | Tweedsmuir · Peebles · Innerleithen · Walkerburn · Galashiels · Melrose · Newstead · St. Boswells · Kelso · Coldstream · Berwick-upon-Tweed |
| Major tributaries (upstream to downstream by confluence) | Cor Water · Talla Water · Holms Water · Lyne Water · Manor Water · Quair Water · Leithen Water · Caddon Water · Ettrick Water · Yarrow Water · Gala Water · River Leader · River Teviot · River Till · Whiteadder Water |
| Major bridges (upstream to downstream) | Neidpath Viaduct · Tweed Bridge · Leaderfoot Viaduct · Dryburgh Bridge · Mertoun Bridge · Rennie Bridge · Hunter Bridge · Coldstream Bridge · Ladykirk and Norham Bridge · Union Bridge · A1 bridge, River Tweed · Royal Border Bridge · Royal Tweed Bridge · Berwick Bridge |